The Erotic Literary Salon – Angel Hogan

I would like to thank all that attended last night’s Salon, what a wonderful event. A dozen plus readers and one Spoken Word by “Mouth”, a magnificent presentation. Angel Hogan our featured presenter for the evening was her spectacular self, truly fine words playing together to create such marvelous poetry.

Angel sent this one particular piece she presented yesterday, welcoming comments and feedback from all attendees and readers of this blog.

Many Distances

The problem with the heart,
a tool of time, is want can never speak.

-Willis Barnstone
And then there is this offer of a mouth

A layering of tongues

Teeth breath, lips, with-with

Barely an idea, a trick

Flickering in the corner of your eye:

Your lover awaits life from your gaze

Your breaker baits a heated barb

Your beloved dies and rises beneath you

Your keeper sinks to your hips

Your warden walks the mighty yard

Your sweetie stays in the strange

Your crush stands in the wind.

Your mistress lifts one aching calf

And bites the tender skin.

Now there are fingers

A layering of flesh,

The almighty touch, a whisper…

Now a flame:

Your lover says your name

Your honey sets the blaze

Your teacher wets your belly

Your partner parts your thighs

Your escort knows your secrets

Your precious lights your skin

Your guide finds you adrift and tangled

then sails you home again.

-Angel Hogan

I also wish to thank Mina Smith-Segal for her lovely watercolors that adorned the Salon last night.

Susana Mayer, PhD

Salonnière & Muse

Tonight – The Erotic Literary Salon event in Philadelphia

Another month has passed, whoosh, hard to believe. For all you folks who have been reading the blog contemplating attending, tonight is the night. The Press Release says it all – under Categories to the right.

If you have attended but never written or read, bring in a piece you enjoy reading at home, or one you have written to a lover. We don’t need to know that if you are shy, but participation is always fun. At least that is what many have said. Then there are others that just enjoy cheering and applauding the brave folks who have bared their sexual souls.

Hope to see you tonight.

Susana Mayer, PhD

Salonnière & Muse

Presents for the HOLIDAY SEASON, ART for SALE, each less than $100

Reminder, tomorrow is the next Salon. Surprise, Frances has changed her flight to Florida to attend one last Salon before she departs for the winter.

Also, please bring extra cash or check. Artwork will be for sale, each piece less than $100. Great presents for the holiday season.

Female Sexual Desire Drug – Boehringer Ingelheim

Muse thoughts. As a clinical sexologist and muse for this Salon I like to keep you abreast of sex in the news. Especially when it can both educate and be used as content for your erotic writings.

As a sexologist I view the new drug being developed by Boehringer Ingelheim as a band-aid for many women who have libido issues. My major complaint is the labeling of female sexual dysfunction, in the field of human sexuality function has not been established yet. I feel each women knows what is her typical behavioral pattern, and often must be educated to what to expect concerning life-span changes and how to deal with them naturally.

We are a society that prefers to pop a pill and ignore all the rest. But just like Viagra® it will not be a panacea for all sexual problems. What is hidden from the public are all the negative psychological effects these drugs have had on relationships.

I don’t want to dismiss these meds completely, but I do want to present caution. I shall now promote my field of sexology. Many attendees have asked me what I do; as a clinical sexologist I focus mainly on women and couples helping them deal specifically with issues of sexual desire, sexual physical pain, and creating passionate sex lives.

There are rare occasions where I suggest a client get a prescription for enhancing drugs. The feedback I usually get is that creating a passionate sex life is far more fun if done naturally.

I’m in the process of creating a website and will keep you posted when it is ready for your appraisal.

The following is an article written about the recent findings of Boehringer Ingelheim. I think the manner in which the drug works would make for interesting writing material.

Hope to see you all Tuesday at the next Salon.

Susana Mayer, PhD

Salonnière & Muse

www.SusanaMayer.com    – site under construction

Desire Drug May Prove Sex Really Is All in Her Head

By Naomi Kresge

Nov. 13 (Bloomberg) — Boehringer Ingelheim GmbH is banking on sex really being all in women’s heads.

The German drugmaker is putting the finishing touches on a pill designed to reawaken desire by blunting female inhibitions. Unlike Viagra, which targets the mechanics of sex by boosting blood flow to the penis, this drug works on the brain.

The desire drug, the focus of a meeting on sexual disorders in Lyon next week, has the potential to revolutionize sexual medicine much as Pfizer Inc.’s blue pill did a decade ago. That could put family-owned Boehringer at the center of a debate about whether the medicine is a chemical shortcut around a complex dysfunction involving body and mind — or whether disinterest in sex is a legitimate medical condition.

“This drug has the potential to finally open the door to acceptance of the idea that decreased desire can be something that involves a dysfunctional way the brain works, and not only a bad partner,” said Jim Pfaus, a neurologist at Concordia University in Montreal, who conducted early tests of the drug in rats. “Of course it’s in your head.”

The U.S. market for medicines to rekindle female libido could be bigger than the $2 billion a year in U.S. sales for erectile dysfunction treatments because more women report sexual problems, BioSante Pharmaceuticals Inc. Chief Executive Officer Stephen Simes estimated last year.

Showing It Works

Boehringer, based in the German town of Ingelheim on the Rhine’s west bank, was searching for a depression treatment in the 1990s when it stumbled on the compound, called flibanserin. By 2002, Boehringer found the drug wasn’t lifting patients’ mood. The company says researchers were startled when test subjects rated one measure of well-being, sexual appetite, consistently higher than the others.

After what Pfaus described as an initial period of hesitation about developing a sex pill, Boehringer decided to move forward. The company needs new drugs because it faces the loss of 1 billion euros ($1.5 billion) in annual revenue when two older medicines, Mirapex for Parkinson’s disease and Flomax to treat enlarged prostate, lose patent protection next year.

The world’s largest closely held pharmaceutical company has been studying flibanserin for more than a decade and it has yet to publish clinical test results showing the drug is effective. The company will lift its veil of secrecy on Monday at the European Society for Sexual Medicine conference with data from trials of more than 5,000 European and U.S. women.

Women’s Distress

The main criterion for the clinical trials, which the company named after flowers, was how many “satisfying sexual events” women said they had experienced after starting treatment. If the results are good, the so-called Bouquet studies, dubbed Violet, Daisy, Dahlia and Orchid, could form the basis for applications to U.S. and European regulators.

The German company is taking a page from Pfizer’s book. The U.S. drugmaker broadened the appeal of Viagra in 1998 by steering clear of the word “impotence” and saying the blue pill addressed a disease called erectile dysfunction. Boehringer is avoiding potentially offensive words such as frigidity and refers to the problem its pill cures by its clinical name, hypoactive sexual desire disorder, or HSDD.

“An increasing body of evidence shows that hypoactive sexual desire disorder causes substantial emotional distress,” said Heike Specht, a spokesman for the company. The drugmaker “has conducted late-stage clinical trials in over 5,000 women from which we hope will result the first available pharmaceutical treatment.”

A Boehringer survey of 31,000 U.S. women aged 18 and above found that one in 10 expressed distress because of diminished sex drive.

Ideological Battle

A sluggish libido is “a real problem,” and early clinical results so far suggest Boehringer’s drug can help, according to Stephen Stahl, a psychopharmacologist and chairman of the Neuroscience Education Institute in Carlsbad, California. Stahl, who has been a consultant for Boehringer, sees a growing role for drugs in treating sexual disorders.

Not everyone agrees there is a disorder to begin with.

In 2003, a year after Boehringer started the Bouquet clinical trials, an article written by Ray Moynihan in the British Medical Journal called female sexual dysfunction “the freshest, clearest example we have” of a disease created by pharmaceutical companies to make healthy people think they need medicine.

“This is for some an ideological battle,” said psychiatrist Michael Berner of the Freiburg University Clinic, who had patients in Boehringer’s studies. “One view is the multi-dimensional view you get from people like me. And then you have these people that say you should work only on relationship issues and that medication cannot have a place.”

‘Like Dancing’

Researchers don’t know why some women’s libido falters, said Pfaus, who has tested compounds in rats for Pfizer, Boehringer and Palatin Technologies Inc. by gauging whether they spur female rats to solicit sex from males.

“An erection is obvious, it’s easy,” Pfaus said. “But desire — how do you get at that?”

The explanation may be partly evolutionary, according to Berner, who says male primates are driven by a need to spread their semen, while for females it’s important to be able to care for and rear the offspring.

Some researchers believe the social components of intercourse mean that sexual problems can’t be addressed in the same way as heart failure or cancer.

Sex is a “historical and cultural phenomenon,” said Leonore Tiefer, a psychiatry professor at New York University. There’s no baseline of normalcy by which to define a disorder, she contends.

“It’s like dancing, or music, or piano-playing,” Tiefer said. “You do it with the body, but the part the body plays isn’t the largest part.”

Over the Wall

Flibanserin works on the brain by putting “two feet on the brakes” to block the release of a chemical called serotonin, which regulates mood, appetite, sleep and memory, Pfaus said. In time, the process should trigger the production of dopamine, a chemical that, among other jobs, helps stimulate desire.

The drug differs from testosterone, a hormone that’s also been tested to reawaken women’s desire. Berner, interviewed at his study in Freiburg, sketched the picture of a wall to explain how flibanserin works.

“You’re standing here, sad, inhibited,” he said, drawing a stick figure next to the wall on a scrap of paper. “Testosterone would give you a little bit more excitement, so you’d climb over. Flibanserin would take away one of the stones.”

Once a Day

The compound takes three to six weeks to kick in. The pill has to be taken daily, and some women taking part in the clinical trials reported feeling tired, Berner said.

Boehringer recruited women for clinical studies using print advertisements. Berner said his patients were largely professionals in their early 30s to mid-40s, and most chose to continue in the trial in a subsequent phase that ensured they would get the real drug instead of a placebo. Boehringer is recruiting older women for a follow-up study.

Women can be diagnosed with hypoactive sexual desire disorder if they feel concerned, bothered or frustrated by a lack of desire — or if it’s hurting their relationships.

The company used personal digital assistants to check whether the pill was working. Participants were beeped once a day and asked to rate their level of desire and say whether they had been sexually active and whether it was enjoyable.

Potential Rivals

If flibanserin makes it to market, it will be the first success after a series of failures from drugmakers including Procter & Gamble Co. and Pfizer. The New York-based maker of Viagra abandoned efforts to adapt its pill for women in 2004 and closed sex-health research at the end of last year.

The only female sexual dysfunction therapy approved in the U.S. is Eros-CTD, from NuGyn, Inc., a suction pump that fits over the clitoris much like the erection pumps that predated Viagra. Intrinsa, a testosterone patch from Noven Pharmaceuticals Inc. licensed by Procter & Gamble, is sold in Europe for women whose uteruses have been removed. A U.S. version was put on hold in 2004 on concern about whether it is safe for long-term use.

Still in clinical trials are a new version of the P&G patch; LibiGel, a testosterone gel from BioSante; and bremelanotide, an injected therapy from Palatin Technologies.

Researchers around the world will be watching Boehringer’s results in Lyon, according to Pfaus. “There are probably a lot of companies holding their breath,” he said.

To contact the reporter on this story: Naomi Kresge in Zurich at nkresge@bloomberg.net

Last Updated: November 13, 2009 06:09 EST